Aging is the number one cause of disability and morbidity in our society, and the
cause of the biggest drain of resources on the healthcare systems in the Western
FAB is working to boost the body’s defences against this damage that accumulates with aging. Our bodies have their own defences, but they decline with age. A decade’s research by FAB’s scientific founder Dr. Bains has identified how that process could be ‘tuned up’ in cells as we age, extending the healthy life of our cells and hence of our bodies.
See the other sections for more background on the chemistry and biology of aging, and how Five Alarm Bio is targeting it.
In a landmark paper, Manuel Serrano and his colleagues listed nine types of failure
that happen in our cells and bodies as we age:
1. DNA damage and instability
2. Altered cell:cell communication
3. Epigenetic alteration
4. Loss or protein quality control
5. Accumulation of senescent cells
6. Running out of stem cells
7. Mitochondrial damage and dysfunction
8. Failure in cellular sensing of nutrients
9. Telomere shortening
Many of these come down to accumulated chemical damage. This is directly seen in the accumulation of compounds called Advanced Glycation Endproducts – AGEs – which damage proteins inside and outside cells, and are the targets of several anti-aging programmes and drugs.
Our approach is to look at the more subtle effects of chemical damage, the degradation of cellular accuracy, and target this for redress.
Our bodies are assaulted by chemicals every second. Even if we drank nothing but pure water and ate only the cleanest, healthiest food, the oxygen in the air we breathe is a reactive substance that damages us, and our own metabolisms generate ‘accidental’ products that are harmful.
Why are all these random chemicals bad? In a landmark paper published in 2016, Five Alarm Bio’s founding scientist William Bains described why any chemical that was not part of the body’s healthy biochemistry is bound to interfere with the actions of enzymes and other proteins throughout the body. This is not just obvious chemical attack. Even small changes in how a protein functions can disrupt the delicate balance of a healthy cell.
Luckily our cells have many defences against such disruption, but they gradually fade with age. A key development of the 2016 work was seeing how those defences could be encouraged to work just a bit harder, to counter the effect of chemistry and hence extend healthy lifespan. This is the technology that Five Alarm Bio is implementing.
To date, Five Alarm Bio is conducting seed-funded
research in Cambridge, UK. Results to date, using a
model compound, have successfully demonstrated
the potential of this novel approach to target the
underlying chemistry of aging.
Future programmes will target this core technology to specific organ systems and their diseases, as well as to deferring aging in the healthy but old.